How high fat diet increase body weight , high blood sugar and cause diabetes

The most effects of  high-fat diet  increase body weight and caused anxiety and depression and high blood sugar along with measurable changes in the brain, the new study in mice revealed. Strangely, that these high-fat diet fed mice did not benefit from treatment with an antidepressant, the researchers said.

Over a servay, The World Health Organization estimates diabetes and depression each affect 350 million people.  These condition in some way intertwined? According to the researchers, past studies suggest  that depressive disorder that develop relatively early in the life lead to an increased risk of diabetes, while 10 to 30 percent of diabetic patients suffer from major type of  depression. Prior to research also shows how metabolic damage caused by a long-term high-fat diets or a Western diet elicited depressed behavior in animals modeling type 1 and type 2 diabetes mellitus.  Past animal studies have also suggested that a high fat diet — consisting mainly of large portions of meat, dairy, and nuts and little to no starches or sugars — might exacerbate depression.

 These findings emphasize the existence of common brain circuits and signaling pathways between both metabolic and psychiatric disorders. 

And  To explore the influence of type 2 diabetes on emotionality, the French research team designed a experiment that worked like this type : First, they fed mice a high fat diet and then assessed the rodents for the metabolic or psychiatric disorder symptom, while also examining their brains. Next, the researchers tested and see whether an antidepressant or withdrawal from the high fat diet could reverse the metabolic and behavioral symptoms in the mice. Finally, they analyzed all the result.

 And some of what they discovered was expected. The high fat diet increased the body weight of the mice while also raising their blood sugar levels and the decreasing their glucose tolerance. Yet these metabolic symptom also correlated with anxiety/depression-like symptom in the mice. And while examination of the mice also revealed decreased serotonin levels in the hippocampus. (Generally, the higher levels of serotonin produce the  positive mood.)

Importantly,over all even prolonged use of an antidepressant produced no beneficial effects on the mice. By comparison, stopping the high fat diet completely reversed the metabolic impairments and lessened the anxious symptoms, and even if some depression-like symptoms remained.

And the researchers says their data provide "clear-cut evidence" that metabolic and psychiatric pathologies are not only related, but also linked to discernible changes in the brain. Based on these findings.